منابع مشابه
Metabolic modulation of neurogenesis
Glutamine plays a key role in many metabolic processes. Deamination of glutamine to glutamate is mediated by 2 enzymes: glutaminase 1 and glutaminase 2. while both isozymes are expressed in the nervous system, our understanding of their regulation and function during development and in brain pathophysiology remains incomplete. The work by Velletri et al. published in Cell Cycle provides importa...
متن کاملMetabolic modulation in dilated cardiomyopathy
Management of patients with dilated cardiomyopathy (DCM) and chronic heart failure (HF) remains challenging. There is a need for novel medical therapies independent of the neurohormonal axis that improve cardiac performance. Experimental and preliminary clinical studies have demonstrated that metabolic modulators enhancing myocardial glucose metabolism directly or indirectly by limiting free fa...
متن کاملMetabolic modulation of glioblastoma with dichloroacetate.
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. This metabolic remodeling is accompanied by mitochondrial hyperpolarization. We tested whether the small-molecule and orphan drug dichloroacetate (DCA) can reverse this cance...
متن کاملMetabolic modulation as a novel cancer treatment
The Warburg effect refers to the cancer’s metabolic shift from mitochondrial oxidation to anaerobic glycolysis, even when oxygen is present. Although this metabolic anomaly was long believed to be due to irreversible mitochondrial damage, it now appears mitochondria in cancer are actively suppressed. Since mitochondria are extensively integrated into the metabolic, signaling and apoptotic biolo...
متن کاملMetabolic Inflammation-Differential Modulation by Dietary Constituents.
Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory response, a key contributor to metabolic diseases such as T2D. Recent studies, focused on the emerging area of metabolic-inflammation, highlight that specific metabolites can modulate the functional nature and inflammatory phenotype of immune cells. In obesity, expanding adipose tissue attracts immune cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.105.2.140